Evidence Synthesis with GRADE and GRADE-CERQual: New Videos

Quantitative Studies: GRADE

GRADE (Grades of Recommendation, Assessment, Development, and Evaluation) is considered an important tool for guiding evidence synthesis in clinical practice guidelines and systematic review development based upon the certainty of evidence. Five specific domains are incorporated in the GRADE approach: Risk of Bias, Publication Bias, Imprecision, Inconsistency, Indirectness.

Published systematic reviews generally present Summary of Findings Tables structured to reflect outcomes across studies via four levels of evidence: High, Moderate, Low, Very Low.

Qualitative Studies: GRADE-CERQual

GRADE-CERQual: represents a framework for assessing Confidence in the Evidence from Reviews of Qualitative Research. Four components contribute to this synthesis: Methodological Limitations, Coherence, Adequacy of Data, Relevance of Data.

The framework’s four levels of grading are High Confidence, Moderate Confidence, Low Confidence, Very Low Confidence.

Recently posted videos provide excellent guidance for each framework:



Please visit the Scott Memorial Library’s Systematic Reviews Guide for additional Evidence Synthesis resources & details.

Questions? Contact askalibrarian (Scott/Center City), AskGutman (Gutman/East Falls), or Wilmerlibrary (Wilmer/Abington).